Recently, the Third Affiliated Hospital of ZZU successfully blocked Adams-Oliver syndrome for the first time through three generations of test-tube baby （PGT-M） technology, resulting in the birth of a healthy baby boy. The safe birth of this new life indicates that the application of three generations of IVF technology in our province has made an important breakthrough in blocking and preventing rare diseases, and has also made a positive contribution to the development of precision medicine and reducing the incidence of birth defects.