A press conference was recently held at the Chinese Academy of Sciences to announce significant achievements in the field of mesoscopic brain mapping, solidify China's leadership in mapping brain circuitry at the mesoscale level, and reveal unprecedented cellular dynamics.
Among them, a groundbreaking study led by Prof Wang Jian's team at Zhengzhou University, in collaboration with other institutions like University of Gothenburg, mapped the world's first spatiotemporal transcriptomic atlas of mouse brain tissue in a hemorrhagic stroke model. Published in the journal Neuron, this research sheds light on the tissue damage and repair processes post-brain hemorrhage, revealing key roles played by different cell types.
The study identified a unique injury repair battlefield in the brain post-hemorrhage, where damaged neurons are gradually replaced by glial cells and immune cells. By the seventh day, these cells completely replace the original neurons, with reactive astrocytes separating the lesion area from healthy tissue. Additionally, the research highlighted that brain hemorrhaging involves not only local but also whole-brain responses.
This achievement marks a significant milestone in understanding the dynamic processes of brain hemorrhage and provides valuable insights for clinical interventions and personalized treatment strategies. It signifies a crucial step towards unraveling brain connectivity mysteries and advancing brain science research, with potential implications for brain disease treatment and neuromorphic intelligence development.